Mucins in cat airway secretions
نویسندگان
چکیده
منابع مشابه
Mucins in airway secretions from healthy and chronic bronchitic subjects.
Little is known about whether the properties of respiratory mucins are altered as a result of airway irritation, but histochemical studies of respiratory tract secretory cells show a more 'acidic' staining pattern after exposure to tobacco smoke. Furthermore it has been suggested that proteoglycans are the major glycoconjugates in 'normal' respiratory secretions, whereas mucins predominate in s...
متن کاملMUC5AC and MUC5B Mucins Are Decreased in Cystic Fibrosis Airway Secretions.
Cystic fibrosis (CF) is characterized by progressive airway obstruction. Although it has been postulated that this is due in part to mucus hypersecretion, there are no published data showing an increase in the gel-forming mucins MUC5AC or MUC5B in CF secretions. We used confocal microscopy to assess the amount of mucin-like glycoprotein and DNA in CF sputum and found more mucin in bronchitis sp...
متن کاملMUC5AC and MUC5B mucins increase in cystic fibrosis airway secretions during pulmonary exacerbation.
RATIONALE Cystic fibrosis (CF) is believed to be associated with mucus hypersecretion; thus, the principal airway gel-forming mucins, MUC5AC and MUC5B, are also expected to be increased relative to non-CF secretions. However, we have shown that these mucins are decreased during stable CF disease. OBJECTIVES In this study, we determine if these mucins increase during a pulmonary exacerbation o...
متن کاملIdentification of MUC5B, MUC5AC and small amounts of MUC2 mucins in cystic fibrosis airway secretions.
To investigate the genetic identities of the mucins secreted in cystic fibrosis (CF) airways, sputum was collected from five individuals. Samples were separated into gel and sol phases by high-speed centrifugation and the gel phase was extracted in 6 M guanidinium chloride. The 'insoluble' residue remaining after extraction of the gel phase was brought into solution by reduction/alkylation. Den...
متن کاملAirway secretions: new concepts and functions.
The editorial board of the European Respiratory Journal has decided to set up in the Journal several series of reviews covering areas of current interest in clinical, as well as in more fundamental molecular and cellular aspects. The first series deals with "Airway secretions: new concepts and functions". Four reviews dealing with this topic will, therefore, appear in succession in the European...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1991
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj2750663